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HLA-B27

Clinical information

The membrane-bound HLA-B27 protein is associated with the occurrence of several autoimmune diseases, such as ankylosing spondylitis (Bechterew's disease). Around 3% to 6% of HLA-B*27 carriers develop ankylosing spondylitis. Approximately 90% of ankylosing spondylitis patients are carriers of this tissue antigen.

Diagnostics

The EUROArray HLA-B27 detects nearly all currently known HLA-B*27 subtypes. Furthermore, when a positive result is obtained, it is indicated whether the subtypes HLA-B*27:06 or HLA-B*27:09 could be involved. These two subtypes are not associated with ankylosing spondylitis. With the unique direct procedure, the DNA no longer needs to be isolated. The blood sample is treated with two extraction reagents and can then be used directly in the PCR. Data analysis, data interpretation and electronic archiving are fully automated with the EUROArrayScan software. Numerous controls on the EUROArray HLA-B27 verify the correctness of the results. For every reaction it is verified that human DNA was present in the PCR and that the primers for the amplification of HLA-B27 were functional, which is particularly relevant when negative HLA-B27 results are obtained. All of these controls ensure a reliable test result with just one PCR reaction.

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EUROArray
EUROArray HLA-B27 Direct
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